SULBENICILLIN SODIUM

PRODUCT IDENTIFICATION
CAS NO. 41744-40-5 (Base)
28002-18-8 (Disodium)

SULBENICILLIN SODIUM
EINECS NO. 255-528-6
FORMULA C16 H16N2O7S2·2Na
MOL WT. 458.42

H.S. CODE

  

TOXICITY

 
SYNONYMS alpha-Sulfobenzylpenicillin disodium; Sulbencillin;
Disodium (2S,5R,6R)-3,3-dimethyl-7-oxo-6-((2R)-2-phenyl-2-sulfonatoacetylamino)-4-thia-1- azabicyclo(3.2.0)heptane-2-carboxylate;
SOURCE

 

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE white to yellowish crystalline powder
MELTING POINT  
BOILING POINT

 
SPECIFIC GRAVITY

 
SOLUBILITY IN WATER  
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

  

REFRACTIVE INDEX

 
FLASH POINT

 
STABILITY

Stable under ordinary conditions.

APPLICATIONS
Penicillin is any of a large group of broad-spectrum antibiotic drugs derived directly or indirectly from molds of the genus Penicillium and other soil-inhabiting fungi grown on special culture media, which exert a bacteriocidal as well as a bacteriostatic effect on susceptible bacteria during their growth stage by the inhibition of biosynthesis of their cell wall mucopeptide. Penicillin, beta-lactam antibiotics, possess a four-ring beta-lactam structure shares a nitrogen and a carbon atom with fused a five-membered thiazolidine ring. These antibiotics have low toxicity for the host but effective against most gram-positive bacteria including pathogens (streptococci, staphylococci, pneumococci); clostridia; some gram-negative gonococci; some spirochetes (Treponema pallidum and T. pertenue); and some fungi. Certain strains of some target species, e.g., staphylococci, secrete the enzyme penicillinase, which inactivates penicillin and confers resistance to the antibiotic.

Sulbencillin is a semisynthetic penicillin which has the active core body of 6-aminopenicillanic acid with modification of sulfonic side chain at alpha position. Suncillin (N-sulfonicpenicillin) is an analogue of sulbencillin. The chemical designation is (2S,5R,6R)-3,3-dimethyl-7-oxo-6-((2R)-2-phenyl-2- sulfonatoacetylamino)- 4-thia-1-azabicyclo (3.2.0)heptane-2-carboxylic acid.

Some modified penicillins at alpha position include:

  • alpha-Sulfonatopenicillins
  • Sulbenicillin Base (CAS #: 41744-40-5)
  • Sulbenicillin Disodium (CAS #: 28002-18-8)
  • Suncillin
  • alpha-Carboxypenicillins
    • Carbenicillin Base (CAS #: 4697-36-3)
    • Indanyl-carbenicillin (CAS #: 35531-88-5)
    • Carbenicillin Indanyl Sodium
    • Carbenicillin Potassium
    • Carbenicillin Disodium (CAS #: 4800-94-6)
    • Carbenicillin Phenyl Sodium or Carfecillin Sodium (CAS #: 21649-57-0)
    • Carfecillin Base (CAS #: 27025-49-6)
    • Ticarcillin Base (CAS #: 4697-14-7 or 34787-01-4)
    • Ticarcillin Cresyl Sodium
    • Ticarcillin Monosodiu
    • Ticarcillin Disodium (CAS #: 74682-62-5)
  • N-acyl group substituted penicillins
    • Apalcillin (CAS #: 63469-19-2)
    • Azlocillin (CAS #: 37091-66-0 or 37091-65-9)
    • Azlocillin Sodium
    • Furbenicillin
    • Furbenicillin Sodium
    • Mezlocillin Base (CAS #: 51481-65-3)
    • Mezlocillin Sodium
    • Piperacillin Base (CAS #: 61477-96-1)
    • Piperacillin Sodium (CAS #: 59703-84-3)
    • Pirbenicillin (CAS #: 55975-92-3)
    SALES SPECIFICATION

    APPEARANCE

    		 white crystalline powder

    IDENTIFICATION

    Complies

    ASSAY

    		 814 - 950 µg/mg min (Anhydrous Basis)
    OPTICAL ROTATION +167° ~ +187°

    HEAVY METALS
    10ppm max

    pH

    5.5 - 7.0

    MOISTURE

    4.0% max
    TRANSPORTATION
    PACKING

    HAZARD CLASS  
    UN NO.  
    OTHER INFORMATION
    Hazard Symbols: XI, Risk Phrases: 36/37/38, Safety Phrases: 26-36
    PRICE INFORMATION

    Click to open the table

     

    Click to close the table